Visual-omics foundation model · spatial agentic module

From H&E to evidence-grounded spatial analysis

HistAgent converts local and surrounding tissue morphology into a ranked molecular readout, organizes the readout into a spot-level evidence card and supports successive questions about the local tissue state.

Multi-scale H&E inputTop-50 gene rankingSpot-level evidence cardsAdapted Qwen3-8B

01 · Input Local and contextual H&E

Two views centered on the same tissue location capture local morphology and the surrounding tissue context.

02 · Molecular inference Ranked molecular readout

The foundation model autoregressively generates an ordered list of up to 50 genes.

03 · Evidence construction Spot-level evidence card

Ranked genes, inferred cell composition, functional programs and spatial context are organized together.

04 · Follow-up analysis Evidence-grounded reasoning

The agentic module answers successive questions while grounding its conclusions in the evidence card.

Interactive workflow

Run HistAgent

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The public demonstration provides live ranked-gene generation and evidence-grounded reasoning with measured reference evidence cards. The first request may wait briefly while a ZeroGPU worker starts. Research use only.